Laboratory No. 2: Synthesis of Antitumor Compounds – Institute of Fine Organic Chemistry (IFOC) at NAS RA STCOPC
Head of the Laboratory: A. Harutyunyan, Doctor of Chemical Sciences
Research Focus
The laboratory specializes in the synthesis and study of novel biologically active compounds, particularly in:
- Development of pharmaceuticals for the treatment of malignant neoplasms
- Creation of compounds for the treatment of bacterial and viral infectious diseases
Key Research Directions
- Discovery of promising drug candidates based on N-, O-, and S-containing five- and six-membered heterocyclic compounds and their derivatives
- Development of polycondensed systems, nucleosides, and hybrid molecules incorporating biologically active compound residues
- Chemical modification of antitumor and antiviral drugs to enhance their efficacy
Chemical Combinatorics and Synthetic Methodology
The laboratory employs combinatorial chemistry techniques for:
- Synthesis of molecules with various mechanisms of antitumor and antiviral activity
- Design of new pharmaceutical compounds by combining structural fragments of organic molecules
- Development of:
- Antimetabolites
- Inhibitors of mitosis and DNA methylation
- Protein biosynthesis inhibitors
- Compounds with photodynamic activity
- Irreversible enzyme and receptor inhibitors
Study of Biologically Active Compounds
The laboratory conducts in vitro and in vivo biological studies, including:
- Computer-aided drug design (CADD) of biologically active compounds
- Analysis of the relationship between biological activity and structural characteristics
- Determination of strategic directions for further research
