Laboratory of X-ray Structural Studies and Mass Spectroscopy

About the Laboratory

Harutyun Arshaluysi Karapetyan

Head of the Laboratory

Candidate of Physical and Mathematical Sciences

📧 Email: harkar60@gmail.com

 

Staff

Services

🔹 X-ray Structural Analysis

  • Decoding and refining the atomic structure of crystalline samples.
  • Determining the three-dimensional crystal structure.
  • Refining isotropic, anisotropic, and anharmonic thermal vibration parameters of atoms.

🔹 Gas Chromatographic Analysis

  • Separation of organic compound mixtures.
  • Determining the concentration of compounds in mixtures.
  • Confirmation of the chemical structures of low-boiling (up to 250°C) compounds using mass spectrometry.

Scientific Research

The laboratory primarily focuses on the relationship between physical properties and atomic structure, as well as biological activity and atomic structure.
Our researchers collaborate with national and international research institutes and universities in the fields of physics and chemistry, ensuring high-quality analytical research.

Equipment

  • CAD-4 “Enraf-Nonius” X-ray Single Crystal Diffractometer
    ✅ Low (120-300K) and high (300-800K) temperature systems.

  • GC/MS Bruker EM 640S Gas Chromatograph Mass Spectrometer

  • LNP-40 CRYOMECH Liquid Nitrogen Generator

Recent Publications (Last 5 Years)

(Here, you can list the publications as bullet points if needed.)

  1. EG Paronikyan, Sh. Sh. Dashyan, IA Dzhagatspanyan, RG Paronikyan, IM Nazaryan, AG Akopyan, NS Minasyan, AG Ayvazyan, RA Tamazyan, EV Babaev, Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines, Russian Journal of Bioorganic Chemistry, 2016, 42 (2), 215-223, DOI. https://doi.org/10.1134/S1068162016020102
  2. Samvel N. Sirakanyan, Domenico Spinelli, Athina Geronikaki, Viktor G. Kartsev, Henrik A. Panosyan, Armen G. Ayvazyan, Rafael A. Tamazyan, Vincenzo Frenna, Anush A. Hovakimyan, The azide/tetrazole equilibrium. an investigation in the series of furo- and thieno[2,3-e] tetrazole[3,2-d] pyrimidine derivatives, Tetrahedron, 2016, 72 (16), 1919-1927, DOI: https://doi.org/10.1016/j.tet.2016.02.048
  3. Geghetsik B. Zakaryan, Sargis S. Hayotsyan, Armen G. Ayvazyan, Rafael A. Tamazyan, Henrik A. Panosyan, Gevorg G. Danagulyan, Hovhannes S. Attaryan, Alkylation of 3-nitro-1,2,4-triazole in aqueous alkaline medium in the presence of N-methylmorpholine N-oxide and verification of the structure of the reaction products, Chemistry of Heterocyclic Compounds, 2016, 52 (4), 253-256, DOI. https://doi.org/10.1007/s10593-016-1870-2
  4. A. Kh. Gyulnazaryan, TA Sahakyan, GT Sargsyan, JV Grigoryan, GM Muradyan, GA Panosyan, RA Tamazyan, AG Ayvazyan, AM Petrosyan, The Stevens rearrangement of propargyl-containing ammonium salts, Russian Journal of General Chemistry, 2016, 86 (5), 1017 -1021, DOI: https://doi.org/10.1134/S1070363216050054
  5. R. Dzh. Khachikyan, ZG Ovakimyan, GA Panosyan, RA Tamazyan, AG Ayvazyan, Features of reactions of (E)-1-(β-aroylvinyl)pyridinium bromides with binucleophiles, Russian Journal of General Chemistry, 2016, 86 (7), 1574-1580 , DOI: https://doi.org/10.1134/S1070363216070070
  6. SP Gasparyan, MV Alexanyan, GK Harutyunyan, AH Martirosyan, HM Stepanyan, RE Muradyan, RA Tamazyan, AG Ayvazyan, Synthesis of 10-(R-benzoyl)-2,4-dimethyl-6-(R-phenyl)-8, 9-dihydropyrimido[5,4-e] pyrrolo:[1,2-c] pyrimidine-1,3(2H,4H)-diones and 2,4-dimethyl-9,10-dihydro-6λ4-pyrimido[5,4-d] pyrrolo-[1,2-b][1,2,6]thiadiazine-1,3,6(2H,4H,8H)-trione, Russian Journal of Organic Chemistry, 2016, 52 (9), 1348-1352, DOI. https://doi.org/10.1134/S1070428016090177
  7. Arutyunyan A. A., Panosyan G. A., Tamazyan R. A., Ayvazyan A. G., New benzo derivatives[4,5] imidazo:[2’,1’:6,1] pyrido[2,3-d] pyrimidine, Chemical Journal of Armenia, 2016, 69 (3), 266-273, URL: http://chemistry.asj-oa.am/id/eprint/7743
  8. Gulnazaryan A. Kh., Sahakyan T. A., Tamazyan R. A., Ayvazyan A. G., Formation of spiroheterocyclic compound during bromination of 1,1-di(prop-2-in-1-yl)piperidin-1-ium bromide, Chemical Journal of Armenia, 2016, 69 (3), 357-361, URL. http://chemistry.asj-oa.am/id/eprint/7754
  9. Ervand G. Paronikyan, Shushanik Sh. Dashyan, Nune S. Minasyan, Grachya M. Stepanyan, Armen G. Ayvazyan, Rafael A. Tamazyan, Synthesis of derivatives of pyrano[3,4-c][1,2,4] triazolo-[4,3-a] pyridine and 8-(pyrazol-1-yl)pyrano[3,4-c] pyridine through pyridine ring rearrangement, Chemistry of Heterocyclic Compounds, 2016, 52 (12), 1078-1086, DOI. https://doi.org/10.1007/s10593-017-2009-9
  10. SP Gasparyan, MV Alexanyan, GK Arutyunyan, SL Kocharov, AH Martirosyan, RA Tamazyan, AG Ayvazyan, HA Panosyan, GG Danagulyan, Synthesis of new derivatives of 5-(3,4-dihydro-2H-pyrrol-5-yl)- pyrimidine, Russian Journal of Organic Chemistry, 2016, 52 (11), 1646-1653, DOI. https://doi.org/10.1134/S1070428016110166
  11. Vergush A. Pivazyan, Emma A. Ghazaryan, Roza S. Shainova, Rafael A. Tamazyan, Armen G. Ayvazyan, Aleksandr P. Yengoyan, Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a] pyrimidin-5-one Derivatives, Journal of Chemistry, 2017, 1-8, DOI. https://doi.org/10.1155/2017/8180913
  12. AA Harutyunyan, HA Panosyan, RA Tamazyan, AG Ayvazyan, GG Danagulyan, 4-alkylated 2-(2,3,5-tri-O-acyl-β-D-ribofuranosyl)- and 2-(2,3,4, 6-tetra-O-acetyl-β-D-glucopyranosyl)-1,2,4-triazine-3,5-diones, Russian Journal of Organic Chemistry, 2017, 53 (4), 573-576, DOI. https://doi.org/10.1134/S1070428017040121
  13. R. Dzh. Khachikyan, ZG Ovakimyan, GA Panosyan, RA Tamazyan, AG Ayvazyan, Features of reactions of (E)-[(2-aroyl)ethenyl]triphenylphosphonium bromides with binucleophiles, Russian Journal of General Chemistry, 2017, 87 (7), 1503- 1509, DOI: https://doi.org/10.1134/S1070363217070106
  14. MA Samvelyan, TV Ghochikyan, SV Grigoryan, RA Tamazyan, AG Ayvazyan, Alkylation of 1,2,4-triazole-3-thiols with haloalkanoic acid esters, Russian Journal of Organic Chemistry, 2017, 53 (6), 935-940, DOI: https://doi.org/10.1134/S1070428017060203
  15. M. Zh. Ovakimyan, GA Gasparyan, A. S. Bichakhchyan, RR Bagratyan, LV Derdzyan, R. А. Tamazyan, A. G. Ayvazyan, Halogenation of quaternary phosphonium salts containing prop-1(2)-enyl group, Russian Journal of General Chemistry, 2017, 87 (8), 1727-1730, DOI. https://doi.org/10.1134/S1070363217080151
  16. AN Khachatryan, RA Tamazyan, AG Ayvazyan, GG Danagulyan, OS Attaryan, Complex formation of PdCl2 with 1-substituted 3,5-dimethylpyrazoles, Russian Journal of Coordination Chemistry, 2017, 43 (11), 765-769, DOI. https://doi.org/10.1134/S1070328417110045
  17. A. Kh. Gyulnazaryan, TA Sahakyan, RA Tamazyan, AG Ayvazyan, GA Panosyan, AB Yeremyan, Formation of pyrrolinium derivatives in the bromination reaction of N,N-dipropargyl ammonium salts, Russian Journal of General Chemistry, 2017, 87 (10), 2282-2286 , DOI: https://doi.org/10.1134/S1070363217100061
  18. HN Khachatryan, SS Hayotsyan, KS Badalyan, AG Ayvazyan, GG Danagulyan, HS Attaryan, Unusual behavior of 3,5-dimethylpyrazole in the aza-Michael reaction with crotonaldehyde in aqueous medium, Russian Journal of Organic Chemistry, 2017, 53 (10) , 1606-1608, DOI: https://doi.org/10.1134/S1070428017100220
  19. Ervand G. Paronikyan, Shushanik Sh. Dashyan, Henrik A. Panosyan, Armen G. Ayvazyan, Rafael A. Tamazyan, Synthesis and structure of diamino derivatives of pyrano-[3,4-c] pyridines and 5,6,7,8-tetrahydroisoquinolines, Chemistry of Heterocyclic Compounds, 2018, 54 (8), 804-811, DOI. https://doi.org/10.1007/s10593-018-2353-4
  20. Armen S. Galstyan, Tariel V. Ghochikyan, Vardges R. Frangyan, Rafael A. Tamazyan, Armen G. Ayvazyan, Synthesis of Novel Derivatives of 1,2,4-Triazoles, ChemistrySelect, 2018, 3 (35), 9981-9985 , DOI: https://doi.org/10.1002/slct.201802243
  21. AA Harutyunyan, GA Panosyan, RA Tamazyan, AG Ayvazyan, GT Gukasyan, GG Danagulyan, Substituted 2-(2-Arylethenyl]pyrimidin-4(3H)-ones. Synthesis and Structure, Russian Journal of Organic Chemistry, 2018, 54 (4), 614-621, DOI. https://doi.org/10.1134/S1070428018040164
  22. AA Harutyunyan, GT Gukasyan, HA Panosyan, RA Tamazyan, AG Ayvazyan, GG Danagulyan, Synthesis and Structure of New Substituted Pyrimidinone with Unsaturated Side Chain, Russian Journal of Organic Chemistry, 2018, 54 (5), 771-775, DOI. https://doi.org/10.1134/S1070428018050160
  23. KS Avetisyan, L. Kh. Galstyan, RA Tamazyan, AG Ayvazyan, Synthesis and Structure of 5,5-Disubstituted N-[4-Methyl-3-phenylfuran-2(5H)-ylidene] -N′-phenylthioureas, Russian Journal of Organic Chemistry, 2018, 54 (7), 1109-1111, DOI. https://doi.org/10.1134/S1070428018070242
  24. VO Topuzyan, VM Kazoyan, RA Tamazyan, AG Ayvazyan, L. Kh. Galstyan, Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids, Russian Journal of Organic Chemistry, 2018 , 54 (9), 1369-1377, DOI. https://doi.org/10.1134/S1070428018090178
  25. Markosyan AI, Hakopyan Kh. S., Ayvazyan AS, Mamyan SS, Ayvazyan AG, Tamazyan RA, Arsenyan FH, Avakimyan JA, Synthesis and antitumor properties of 3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)spiro[benzo[h] quinazoline-5,1′-cycloheptan]-4(6H)-ones, Chemical Journal of Armenia., 2018, 71(4), 596-608, URL: http://chemistry.asj-oa.am/id/eprint/7910
  26. Ovakimyan M. Zh., Gasparyan G. Ts., Poghosyan AS, Bichakhchyan AS, Derdzyan LV, Tamazyan RA, Ayvazyan AG, Synthesis and peculiarities in the reactions of cyclohex-2-enyltriphenylphosphonium bromide with SH- and NH-containing compounds, Chemical Journal of Armenia, 2018, 71(3), 428-433, URL: http://chemistry.asj-oa.am/id/eprint/7890
  27. Iradyan M. A., Iradyan N. S., Ambartsumyan A. A., Panosyan G. A., Tamazyan R. A., Ayvazyan A. G., Oganesyan G. Sh., Alves de Sousa R., Sakanyan V. A., Selective N-, S-alkylation of 4-allyl-3-[2-(4-алкоксифенил)хинолин-4-ил]-4,5-dihydro-1H-1,2,4-triazol-5-thiones substituted with benzyl chlorides. Synthesis, docking analysis and cytotoxic action, Chemical Journal of Armenia, 2018, 71(3), 389-406, URL: http://chemistry.asj-oa.am/id/eprint/7886
  28. Gulnazaryan A. Kh., Sahakyan T. A., Eremyan A. B., Muradyan G. M., Tamazyan R. A., Ayvazyan A. G., Panosyan G. A., Bromination of ammonium salts containing prop-2-yn-1-yl group, Chemical Journal of Armenia, 2018, 71(3), 352-358, URL: http://chemistry.asj-oa.am/id/eprint/7882
  29. Ayotsyan S. S., Sargsyan A. A., Khachatryan A. Kh., Badasyan A. E., Panosyan G. A., Ayvazyan A. G., Kikoyan N. M., Konkova S. G., Sargsyan M. S., On the possibility of Michael’s retroreaction during the interaction of arylideneacetoacetic ether with amides of acetoacetic acid, Chemical Journal of Armenia, 2018, 71 (1-2), 126-139, URL. http://chemistry.asj-oa.am/id/eprint/7860
  30. EG Paronikyan, Sh. Sh. Dashyan, SS Mamyan, RA Tamazyan, AG Ayvazyan, Efficient Synthesis and Some Transformations of 1-Hydrazinyl-5,6,7,8-tetrahydroisoquinolines Involving Rearrangement of the Pyridine Ring, Russian Journal of Organic Chemistry, 2019, 55 (9), 1351-1362, DOI: https://doi.org/10.1134/S1070428019090148
  31. RM Hakobyan, Synthesis of symmetric bis-isoquinolidones, Russian Journal of Organic Chemistry, 2019, Vol. 55, no. 8, pp. 1296-1299, DOI. https://doi.org/10.1134/S1070428019080268
  32. SS Hayotsyan, AA Sargsyan, SG Konkova, A. Kh. Khachatryan, AE Badasyan, KA Avagyan, HA Panosyan, AG Ayvazyan, MS Sargsyan, Synthesis of Ethyl 5-(Arylcarbamoyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylates, Russian Journal of Organic Chemistry, 2019, 55 (4), 469-472, DOI: https://doi.org/10.1134/S1070428019040080
  33. Gulnazaryan A. Kh., Sahakyan T. A., Muradyan G. M., Ayvazyan A. G., Tamazyan R. A., Panosyan G. A., Formation of (Е)-1-(2,3-dibromoallyl)-1-(2,3-dihydroxypropyl)piperidinium bromide during bromination of ammonium salt containing propargyl and 1,3-dioxolane groups, Chemical Journal of Armenia, 2019, 72(1-2), 142-149, URL. http://chemistry.asj-oa.am/id/eprint/7934
  34. Hasratyan AH, Konkova SG, Hayotsyan SS, Zakaryan GV, Markosyan AJ, Hakobyan RM, Attaryan HS., Study of the reaction of hydrolysis of 1,3-dichlorobut-2-ene in the n-methylmorpholine n-oxide-water system in the presence of sodium hydroxide, Chemical Journal of Armenia. 2019 , 72 (3). pp. 300-303, URL: http://chemistry.asj-oa.am/id/eprint/7952
  35. AA Harutyunyan, GT Gukasyan, HA Panosyan, RA Tamazyan, AG Ayvazyan, GG Danagulyan, Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure, Russian Journal of Organic Chemistry, 2019, 55 (9), 1363-1369, DOI: https://doi.org/10.1134/S107042801909015X
  36. Hakobyan RM, Hayotsyan SS, Attaryan HS, Melikyan GS, Synthesis of pyridone-substituted furan-2(5H)-ones and their intramolecular cyclization to afford furo[3,4-f] isoquinolines, Chem. Heterocycl. Compd., 2019, 55, 1245, DOI: https://doi.org/10.1007/s10593-019-02608-0
  37. Sargsyan M. S., Avagyan K. A., Sargsyan A. A., Badasyan A. E., Khachatryan A. Kh., Ayvazyan A. G., Balyan A. A., Konkova S. G., Ayotsyan S. S., Interaction of arylmethylidenmalononitrile with arylamidoesters of malonic acid. Synthesis of polyfunctionally substituted 1,2,3,4-tetrahydropyridines, Chemical Journal of Armenia, 2019, 72(3), 304-312, URL: http://chemistry.asj-oa.am/id/eprint/7953
  38. VV Dabaeva, MR Baghdasaryan, EG Paronikyan, RA Tamazyan, AG Ayvazyan, Sh. Sh. Dashyan, Synthesis of New Fused Furo- and Thienopyridines, Russian Journal of General Chemistry, 2020, 89 (12), 2364-2368, DOI. https://doi.org/10.1134/S1070363219120065
  39. Aleksandr P. Yengoyan, Zhermen A. Azaryan, Vergush A. Pivazyan, Emma A. Ghazaryan, Rafael A. Tamazyan, Armen G. Ayvazyan, Synthesis and Preliminary Biological Properties Assessment of Novel 2-S-, 4-, 5-Substituted and Bicyclic Derivatives of 6-Methylpyrimidine-4-ol, Letters in Organic Chemistry, 2020, 17 (2), 149-156, DOI. 10.2174/1570178616666190411110415
  40. AA Harutyunyan, GT Gukasyan, HA Panosyan, RA Tamazyan, AG Ayvazyan, AS Grigoryan, G. G Danagulyan, Synthesis of New Benzo Derivatives[4′,5′] imidazo:[2′,1′:6,1] pyrido:[2,3-d] pyrimidine, Russian Journal of Organic Chemistry, 2020, 55 (11), 1698-1703, DOI: https://doi.org/10.1134/S1070428019110095
  41. Hasratyan A. H., Sukoyan AH, Bolyan LA, Hakobyan RM, Tamazyan RA, Ayvazyan AG, Danagulyan GG, Attaryan OS, Study of the complexation of gold (III) with 1-vinylimidazole, Chemical Journal of Armenia, 2020, 73, 37-43 , URI: http://chemistry.asj-oa.am/id/eprint/7995
  42. Sargsyan M. S., Avagyan K. A., Sargsyan A. A., Badasyan A. E., Khachatryan A. Kh., Manukyan A. G., Ayvazyan A. G., Synthesis of alkyl 1-aryl-6-amino-2-oxo-5-cyano-1,2-dihydropyridine-3-carboxylates, Chemical Journal of Armenia, 2020, 73, 61-68, URL. http://chemistry.asj-oa.am/id/eprint/7997
  43. Avetisyan K. S., Galstyan L. Kh., Tamazyan R. A., Ayvazyan A. G., X-ray structural study of the structure of the product interaction of functionally substituted 2(5H)-furanylidentiocarbamides with the ethyl ester of chloroacetic acid, Chemical journal of Armenia, 2020, 73, 251-254, URL. http://chemistry.asj-oa.am/id/eprint/8019
  44. Sargsyan M. S., Avagyan K. A., Sargsyan A. A., Badasyan A. E., Khachatryan A. Kh., Manukyan A. G., Panosyan G. A., Ayvazyan A. G., One-reactor three-component method of synthesis of highly functionalized 1,2,3,4-tetrahydropyridines, Chemical Journal of Armenia, 2020, 73, 391-400, URL: http://chemistry.asj-oa.am/id/eprint/8037
  45. NG Hobosyan, KV Balyan, HS Nersisyan, LM Galechyan, AB Sargsyan, RA Tamazyan, AG Ayvazyan, Features of the Reaction of Dimedone with Some Amines in the Presence of Mercury(II) Acetate, Russian Journal of General Chemistry, 2021, 90 ( 12), 2518-2521, DOI: https://doi.org/10.1134/S1070363220120312
  46. Ervand G. Paronikyan, Shushanik Sh. Dashyan, Suren S. Mamyan, Armen G. Ayvazyan, Dimroth rearrangement in the row of new pyrano[3,4-c][1,2,4]triazolo:[4,3-a][1,5-a]pyridines and synthesis of new heterocyclic systems. Pyranopyrazolo[4,3-e][1,2,4]triazolopyridines, Journal of Heterocyclic Chemistry, Volume58, Issue10, 2021, Pages 1936-1942, DOI. https://doi.org/10.1002/jhet.4319
  47. Samvel N. Sirakanyan, Domenico Spinelli, Victor A. Kartsev, Athina Geronikaki, Elmira K. Hakobyan, Armen G. Ayvazyan, Rafael A. Tamazyan, Anush A. Hovakimyan, A Study of the Regiochemistry in the Synthesis of Pyrano[3,4-c] pyridines, Current Organic Chemistry, VOLUME. 25, ISSUE: 14, Year: 2021, Page:[1704 – 1714] , DOI: 10.2174/1570179418666210621092546
  48. Dashyan Sh.Sh., Balyan K.V., Ayvazyan A.G., Synthesis and structure of new mono- and bicyclic N-/S-propargyl substituted pyridine derivatives. All-Russian congress on the chemistry of heterocyclic compounds “K OST -2021″ , г. Sochi, 2021, p. 345 .
  49. Ginosyan Aghavni, Prazyan Anna, Davinyan Andranik and Hovhannisyan Areg. Effect of γ-Cyclodextrin on the Dissolution of Ginsenosides Rg5 and Rk1 from Red Ginseng Chewable Tablets. Global Journal of Pharmacy and Pharmaceutical science. Volume 9 issue 4 February 2022. DOI:1019080/GJPPS.2022.09.555766.
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